Neo-adjuvant chemotherapy was feasible (75% of patients received all three cycles of chemotherapy), resulted in a good response rate (49% ) and down-staging in 31% (25%-37%) of patients, and did not alter the type or completeness of the surgery (lobectomy: S: 56%, CT-S: 60%, complete resection: S: 80%, CT-S: 82%). Most (61%) were clinical stage I, with 31% stage II, and 7% stage III. Results 519 patients were randomised (S: 261, CT-S: 258) from 70 centres in the UK, Netherlands, Germany, and Belgium. This study is registered as an International Standard Randomised Controlled Trial, number ISRCTN25582437. The primary outcome measure was overall survival, which was analysed on an intention-to-treat basis. Before randomisation, clinicians chose the chemotherapy that would be given from a list of six standard regimens. Methods Patients were randomised to receive either surgery alone (S), or three cycles of platinum-based chemotherapy followed by surgery (CT-S). In the 1990s, much interest was generated from two small trials that reported striking results with neo-adjuvant chemotherapy, and therefore our intergroup randomised trial was designed to investigate whether, in patients with operable non-small cell lung cancer of any stage, outcomes could be improved by giving platinum-based chemotherapy before surgery. Such is the scope of Swift’s commercial might, and the enduring artistic power of her Speak Now era.Īlthough all six “From The Vault” songs are worth enjoying, here is our preliminary ranking of the new goodies from Taylor Swift’s Speak Now (Taylor’s Version).Background Although surgery offers the best chance of cure for patients with non-small cell lung cancer (NSCLC), the overall 5-year survival rate is modest, and improvements are urgently needed. Some of the songs from the Speak Now sessions that Swift has revived for its re-recording focus on the windswept romance and callous betrayal that we’ve played back for years, and fit neatly next to tracks like “Mine,” “Sparks Fly,” “Dear John” and “Enchanted.” Yet Swift - who worked with regular collaborators Jack Antonoff and Aaron Dessner on the “Vault” songs - also gave them a modern sensibility, both by bringing in new voices like Fall Out Boy’s Patrick Stump and Paramore’s Hayley Williams as well as delivering the musical dexterity of her most recent projects to a group of songs that were formed years ago.Īll six of these “From The Vault” songs sound like they could become hits in 2023 - hell, the best track here should become a hit in 2023. Speak Now showcased Swift’s aesthetic command and solidifying point of view during a period of personal growth, and the six “From The Vault” songs on Speak Now (Taylor’s Version) are of a piece with that growth. Of course, the “From The Vault” songs from Speak Now (Taylor’s Version), the newly released re-recording of Swift’s 2010 album, should foremost be considered within the framework of her third studio album, a country-pop masterpiece solely written by Swift as her teens gave way to her twenties. Swift has become so ubiquitous, her connection to her fans so omnipresent, that her smashes are defying time and space - and now, we have six more tracks that could potentially join that hit parade. A 10-minute version of the 2012 song “All Too Well”? That one topped the Hot 100 in 2021. “Karma” kept climbing the Hot 100 before it received an official video or remix, and has quickly become one of the biggest moments from Midnights. “Cruel Summer” was released four years ago, but the Lover standout has morphed into one of the biggest hits of this season, simply because her fans willed it to happen. In 2023, any Taylor Swift song can become a hit.
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